MSM (Methylsulfonylmethane) for pain, inflammation , allergies and overall health
Published at 30.05.2014

Sulfur is the third most abundant mineral in the human body. Skin, nails, hair, connective tissue, cartilage contain sulfur molecules.
The sulfur ensures the permeability of cell membranes, the proper activity of the enzymes, the production of cellular energy, and plays an essential role in blood circulation, and in the body metabolism.

Methylsulfonylmethane (abbreviation: MSM) is a natural form of organic sulfur that can be found in milk and dairy products, fruits and vegetables, meat and fish. It is found in large quantities in cruciferous also: broccoli, cabbage and cauliflower. Unfortunately, being the MSM a water-soluble mineral, it's is drastically eliminated during food preparation procedure.


According to studies, MSM and the related compounds DMSO (dimethylsulfoxide ) and DMS (dimethyl sulphide) provide 85 % of the sulfur found in all living organisms.

MSM that comes from DMSO (to which is added an oxygen atom, MSM = DMSO2 ) which is a single therapeutic agent used worldwide for many purposes. MSM has all the properties of DMSO less its unpleasant odor and some side effects.

MSM : the main uses

Pain and inflammation
The most renowned use is for pain and inflammation either chronic and acute.

The ability of the MSM to maintain a good cellular permeability allows cells to easily elimintaes toxic substances (lactic acid , toxins) and increase the assimilation of nutrients, thus reducing inflammation. Therefore, MSM can be used for inflammation and pain either acute and chronic, such as bursitis, tendonitis, neuralgia, sciatica, headaches, muscle aches, joint pain, back pain, carpal tunnel syndrome, arthritis, rheumatoid arthritis, systemic lupus erythematosus.

Autoimmune Diseases
MSM fights the inflammation associated with autoimmune diseases such as arthritis, rheumatoid arthritis, osteoarthritis, psoriatic arthritis, fibromyalgia, lupus, scleroderma, and so on. Numerous studies have documented that MSM reduces joint degeneration and inflammation.

Allergies and Infections
Thanks to the ability of MSM to bind to cell mucous membranes, this form of sulfur is a natural defense between the body and pathogens agents or allergens.
In fact, MSM has been documented to be useful for parasitic infections and for allergies. MSM has been reported to be able to reduce allergic reactions to several type of allergens.

Some studies focused on the use of MSM in diabetic subjects. They showed that 2 grams of MSM per day help imporbing the balance of blood sugar levels. Indeed, sulfur plays a role in the metabolism of sugars and insulin production. Moreover, increasing the permeability of the cells, MSM helps the absorption of glucose.

Assimilation of nutrients
MSM is also considered an booster of many vitamins and nutrients, since it helps the assimilation of nutrients making cells more permeable to them.
Increasing cell membranes permeability, MSM supports the ability of cells to get rid of toxins, thus it supports the body's detoxification ability.

Also plays the role as antioxidant, thanks to its ability to bind free radicals and make them inactive. It's also necessary for the formation of glutathione, a powerful antioxidant.

Cancer and traditional therapies
MSM is often considered an antioxidant able to help the prevention of many disorders including tumors and cancer.

By increasing cell permeability, the MSM is often recommended as a supplement for those undergoing chemotherapy or radiation therapy, as it might help the action of these traditional treatments.

Central Nervous System
MSM is one of the few antioxidants that can pass the blood-brain barrier. For this reason, it prevents oxidative stress and helps the permeability of nerves and brain cells, this being useful in cases of pain and neurological disorders as well (eg, sciatica , headaches, Bell's palsy, sindorme carpal tunnel , etc.).

Muscle pain and cramps
Often used in combination with vitamin C, MSM has shown the ability to reduce or eliminate the incidence of pain and muscle cramps. It's a useful support either for elderly people who suffer from night cramps or muscle stiffness and athletes to help the recovery after exercise.

Acidity and constipation
Some studies have shown that MSM helps to reduce the acidity of the stomach and constipation problems.

Respiratory system
MSM helps the body to absorb oxygen more effectively by increasing the elasticity and permeability of lung cells and throughout the body, and reducing the formation of red blood cells clottinh. Many individuals suffering from lung disorders (such as emphysema) have reported an improvement in their conditions when taking MSM.

Many users of MSM have reported an improvement in their ability to resist to stress.

Skin Health
Sulfur supports skin, hair and nails health, because it is essential in the production of collagen and keratin. Numerous studies have shown that oral doses of MSM are helpful against acne, rosacea and dry or scaly skin. MSM can also be used topically as a gel or lotion to help relieving psoriasis, eczema, dermatitis, dandruff, scabies, diaper rash and certain fungal infections. The MSM gel can also be applied directly on scars and burns to improve their appearance .

Other Uses
MSM can be taken to support the health of:

  • Eyes: prevention of cataracts , injuries.
  • Gastrointestinal : heartburn , acid reflux , hyperacidity , ulcers, side effects from anti -inflammatory drugs NSAIDs , inflammatory bowel disease , spastic colon , Crohn's disease
  • Mouth, oral hygiene, toothache, jaw disorders ( TMJ )
  • Insect stings and bites : bites and stings , insect repellent , giardia .
  • Circulation : cold hands and feet

MSM : Toxicity and Dosage

In biology, MSM is rated as one of the least toxic substances: it has a degree of toxicity similar to water's one. Salt we commonly use in our foods is much more toxic.
Although rarely, some users have reported reactions such as mild diarrhea  skin rash, headache or fatigue: these are considered detoxification reactions and they usually disappear after a couple of days and/or by reducing the dosage of your MSM supplement.

A single dose is not effective to improve symptoms, therefore MSM should be taken many times during the day. Significant results are usually obtained within three weeks of usage. The recommended single dose ranges between 100 and 1000 mg. The total daily dose may vary from 100 to more than 5000 mg .

The actual dosage depends on the nature, severity of the symptoms and the level of MSM already present in the bloodstream. Healthy people have levels of MSM of at least 1 ppm (parts per million ), while those who suffer from pain, inflammation or any of the conditions mentioned above have been shown to have much lower levels. However, it is not necessary to undergo blood tests to find the  level of MSM in your blood: an excessive amount won't be harmful, considering the absolute non-toxicity of this substance.

MSM can be administered in crystalline powder form or in its aqueous solution. Generally, it's consumed in capsules or tablets of 100 -1000 mg each.